34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
Freshman Organic Chemistry (CHEM 125) Professor Barry Sharpless of Scripps describes the Nobel prize-winning development of titanium-based catalysts for stereoselective oxidation, the mechanism of their reactions, and their use in preparing esomeprazole. Conformational energy of cyclic alkanes illustrates the use of molecular mechanics. 00:00 - Chapter 1. Introduction for Professor Barry Sharpless 02:52 - Chapter 2. The Reactivity of Allyic Alcohols and Vanadium-Catalyzed Epoxidations 11:44 - Chapter 3. Research with Katsuki and the Discovery of Combining Titanium with Tartaric Acid 21:10 - Chapter 4. The Mechanism for Asymmetric Epoxidation of Olefins and the Story of Nexium 41:05 - Chapter 5. The Conformation of Rings: Carvone and Cyclohexane Complete course materials are available at the Open Yale Courses website: open.yale.edu This course was recorded in Fall 2008.
Keywords: Sharpless, TBHP, t-butylhydroperoxide, titanium, epoxidation, allylic alcohol, tartarate, tartaric acid, diethyl tartrate
Categories:
Catalysts,
Conformation,
Cycloalkanes,
Oxidation,
Sharpless
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